MarketGrader Developed Markets (ex-Australia) Health Care Index


Five Largest Companies
Symbol Name Grade Market Cap Country
LLY Eli Lilly and Company 77.0 ¤1,019,830 US
JNJ Johnson & Johnson 51.6 ¤556,766 US
MRK Merck & Co., Inc. 54.7 ¤296,971 US
AZN.GB AstraZeneca PLC 60.0 ¤292,066 GB
NOVO.B.DK Novo Nordisk A/S Class B 76.4 ¤201,030 DK

Five Smallest Companies
Symbol Name Grade Market Cap Country
326030.KR SK Biopharmaceuticals Co., Ltd. 79.5 ¤4,959 KR
YPSN.CH Ypsomed Holding AG 70.4 ¤5,519 CH
4151.JP Kyowa Kirin Co., Ltd. 66.8 ¤8,015 JP
HALO Halozyme Therapeutics, Inc. 73.6 ¤8,143 US
ALK.B.DK ALK-abello A/S Class B 73.1 ¤9,191 DK

Companies with Most Selections Among Current Components
Symbol Name Grade Times* Country
NOVO.B.DK Novo Nordisk A/S Class B 76.4 38 DK
AMGN Amgen Inc. 62.2 31 US
ISRG Intuitive Surgical, Inc. 72.2 27 US
RMD ResMed Inc. 67.4 25 US
JNJ Johnson & Johnson 51.6 24 US
LLY Eli Lilly and Company 77.0 23 US
4507.JP Shionogi & Co., Ltd. 70.4 22 JP
BMY Bristol-Myers Squibb Company 61.9 22 US
4519.JP Chugai Pharmaceutical Co., Ltd. 65.6 21 JP
7741.JP HOYA CORPORATION 68.5 21 JP
*Number of times selected at Index semi-annual reconstitutions since inception date.
Index Bio
Average Market Cap ¤82,486
Median Market Cap ¤24,226
Avg. 3 Mo. Dollar Vol. ¤341,373,766
Avg. 3 Mo. Trading Vol. 2,595,054
Last Rebalance Date 03/23/2026
Companies Replaced 11
Biggest Industry Increase Medical Specialties
Biggest Industry Decrease Pharmaceuticals: Major

Fundamental Attributes
Trailing P/E Ratio (12 Mo.) 24.7
Forward P/E Ratio (12 Mo.) 19.0
Price/Book Ratio 6.4
Avg. Revenue Chg. - 3 Yr 40.9%
Avg. Op. Income Chg. - 3 Yr. 92.0%
Avg. EPS Growth - 3 Yr. 25.3%
Avg. EPS Growth - 1 Yr. 16.7%
Avg. Operating Margin 25.9%
Avg. LT Debt to Total Capital 23.6%
Avg. Return on Equity 23.0%
Dividend Yield 0.4%
Index Average Grade
Developed Markets (ex-Australia) Health Care Index 67.38
Country Breakdown
United States Of America 58.0%
Japan 14.0%
Korea, Republic Of 6.0%
Denmark 4.0%
United Kingdom 4.0%
Israel 2.0%
Finland 2.0%
France 2.0%
Belgium 2.0%
Switzerland 2.0%
Netherlands 2.0%
New Zealand 2.0%
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