MarketGrader Developed Markets (ex-Australia) Health Care Index


Five Largest Companies
Symbol Name Grade Market Cap Country
LLY Eli Lilly and Company 76.4 ¤1,196,229 US
AZN.GB AstraZeneca PLC 62.5 ¤262,042 GB
AMGN Amgen Inc. 67.6 ¤236,981 US
NOVO.B.DK Novo Nordisk A/S Class B 68.5 ¤173,870 DK
ISRG Intuitive Surgical, Inc. 61.7 ¤151,245 US

Five Smallest Companies
Symbol Name Grade Market Cap Country
4151.JP Kyowa Kirin Co., Ltd. 65.3 ¤7,936 JP
ALK.B.DK ALK-abello A/S Class B 67.0 ¤8,090 DK
TGTX TG Therapeutics, Inc. 62.0 ¤8,143 US
PTGX Protagonist Therapeutics, Inc. 67.4 ¤8,935 US
KRYS Krystal Biotech, Inc. 69.8 ¤9,536 US

Companies with Most Selections Among Current Components
Symbol Name Grade Times* Country
NOVO.B.DK Novo Nordisk A/S Class B 68.5 39 DK
AMGN Amgen Inc. 67.6 32 US
ISRG Intuitive Surgical, Inc. 61.7 28 US
RMD ResMed Inc. 65.3 26 US
REGN Regeneron Pharmaceuticals, Inc. 59.4 25 US
LLY Eli Lilly and Company 76.4 24 US
4507.JP Shionogi & Co., Ltd. 71.5 23 JP
BMY Bristol-Myers Squibb Company 67.0 23 US
4519.JP Chugai Pharmaceutical Co., Ltd. 65.4 22 JP
7741.JP HOYA CORPORATION 75.2 22 JP
*Number of times selected at Index semi-annual reconstitutions since inception date.
Index Bio
Average Market Cap ¤70,175
Median Market Cap ¤24,168
Avg. 3 Mo. Dollar Vol. ¤316,736,433
Avg. 3 Mo. Trading Vol. 2,331,940
Last Rebalance Date 09/21/2026
Companies Replaced 11
Biggest Industry Increase Managed Health Care
Biggest Industry Decrease Pharmaceuticals: Major

Fundamental Attributes
Trailing P/E Ratio (12 Mo.) 23.8
Forward P/E Ratio (12 Mo.) 20.2
Price/Book Ratio 5.3
Avg. Revenue Chg. - 3 Yr 42.1%
Avg. Op. Income Chg. - 3 Yr. 83.8%
Avg. EPS Growth - 3 Yr. 23.1%
Avg. EPS Growth - 1 Yr. 15.9%
Avg. Operating Margin 26.9%
Avg. LT Debt to Total Capital 23.3%
Avg. Return on Equity 22.1%
Dividend Yield 0.1%
Index Average Grade
Developed Markets (ex-Australia) Health Care Index 68.37
Country Breakdown
United States Of America 62.0%
Japan 16.0%
Korea, Republic Of 4.0%
Denmark 4.0%
Finland 2.0%
France 2.0%
United Kingdom 2.0%
Ireland 2.0%
Netherlands 2.0%
New Zealand 2.0%
Belgium 2.0%
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