MarketGrader Developed Markets (ex-Australia) Health Care Index


Five Largest Companies
Symbol Name Grade Market Cap Country
LLY Eli Lilly and Company 77.3 ¤1,101,705 US
JNJ Johnson & Johnson 54.7 ¤620,766 US
MRK Merck & Co., Inc. 54.3 ¤316,952 US
AZN.GB AstraZeneca PLC 64.0 ¤251,423 GB
AMGN Amgen Inc. 61.8 ¤220,109 US

Five Smallest Companies
Symbol Name Grade Market Cap Country
326030.KR SK Biopharmaceuticals Co., Ltd. 79.9 ¤4,515 KR
YPSN.CH Ypsomed Holding AG 68.9 ¤5,787 CH
ALK.B.DK ALK-abello A/S Class B 74.9 ¤7,598 DK
4151.JP Kyowa Kirin Co., Ltd. 65.3 ¤8,154 JP
PODD Insulet Corporation 77.0 ¤9,230 US

Companies with Most Selections Among Current Components
Symbol Name Grade Times* Country
NOVO.B.DK Novo Nordisk A/S Class B 77.2 38 DK
AMGN Amgen Inc. 61.8 31 US
ISRG Intuitive Surgical, Inc. 67.2 27 US
RMD ResMed Inc. 66.6 25 US
JNJ Johnson & Johnson 54.7 24 US
LLY Eli Lilly and Company 77.3 23 US
4507.JP Shionogi & Co., Ltd. 72.6 22 JP
BMY Bristol-Myers Squibb Company 67.6 22 US
4519.JP Chugai Pharmaceutical Co., Ltd. 65.4 21 JP
7741.JP HOYA CORPORATION 75.2 21 JP
*Number of times selected at Index semi-annual reconstitutions since inception date.
Index Bio
Average Market Cap ¤86,401
Median Market Cap ¤29,856
Avg. 3 Mo. Dollar Vol. ¤377,669,749
Avg. 3 Mo. Trading Vol. 2,829,570
Last Rebalance Date 03/23/2026
Companies Replaced 11
Biggest Industry Increase Medical Specialties
Biggest Industry Decrease Pharmaceuticals: Major

Fundamental Attributes
Trailing P/E Ratio (12 Mo.) 23.7
Forward P/E Ratio (12 Mo.) 19.0
Price/Book Ratio 6.4
Avg. Revenue Chg. - 3 Yr 42.8%
Avg. Op. Income Chg. - 3 Yr. 91.6%
Avg. EPS Growth - 3 Yr. 24.1%
Avg. EPS Growth - 1 Yr. 17.8%
Avg. Operating Margin 27.0%
Avg. LT Debt to Total Capital 25.9%
Avg. Return on Equity 23.4%
Dividend Yield 0.4%
Index Average Grade
Developed Markets (ex-Australia) Health Care Index 67.67
Country Breakdown
United States Of America 58.0%
Japan 14.0%
Korea, Republic Of 6.0%
Denmark 4.0%
United Kingdom 4.0%
Israel 2.0%
Finland 2.0%
France 2.0%
Belgium 2.0%
Switzerland 2.0%
Netherlands 2.0%
New Zealand 2.0%
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