MarketGrader Developed Markets (ex-Australia) Health Care Index


Five Largest Companies
Symbol Name Grade Market Cap Country
LLY Eli Lilly and Company 66.5 ¤708,072 US
NOVO.B.DK Novo Nordisk A/S Class B 70.0 ¤323,877 DK
ISRG Intuitive Surgical, Inc. 66.5 ¤198,309 US
MRK Merck & Co., Inc. 72.4 ¤191,466 US
AMGN Amgen Inc. 62.2 ¤155,112 US

Five Smallest Companies
Symbol Name Grade Market Cap Country
SRPT Sarepta Therapeutics, Inc. 26.7 ¤3,709 US
326030.KR SK Biopharmaceuticals Co., Ltd. 71.6 ¤5,181 KR
SFZN.CH Siegfried Holding AG 52.7 ¤5,265 CH
LNTH Lantheus Holdings Inc 60.7 ¤5,336 US
HLUN.B.DK H. Lundbeck A/S Class B 69.9 ¤5,734 DK

Companies with Most Selections Among Current Components
Symbol Name Grade Times* Country
NOVO.B.DK Novo Nordisk A/S Class B 70.0 36 DK
BIIB Biogen Inc. 52.4 30 US
AMGN Amgen Inc. 62.2 29 US
ISRG Intuitive Surgical, Inc. 66.5 25 US
REGN Regeneron Pharmaceuticals, Inc. 58.2 23 US
RMD ResMed Inc. 73.0 23 US
EW Edwards Lifesciences Corporation 44.3 22 US
LLY Eli Lilly and Company 66.5 21 US
4507.JP Shionogi & Co., Ltd. 60.7 20 JP
4519.JP Chugai Pharmaceutical Co., Ltd. 66.2 19 JP
*Number of times selected at Index semi-annual reconstitutions since inception date.
Index Bio
Average Market Cap ¤55,624
Median Market Cap ¤14,681
Avg. 3 Mo. Dollar Vol. ¤340,453,415
Avg. 3 Mo. Trading Vol. 3,786,399
Last Rebalance Date 03/24/2025
Companies Replaced 16
Biggest Industry Increase Pharmaceuticals: Major
Biggest Industry Decrease Medical Specialties

Fundamental Attributes
Trailing P/E Ratio (12 Mo.) 25.7
Forward P/E Ratio (12 Mo.) 20.5
Price/Book Ratio 4.6
Avg. Revenue Chg. - 3 Yr 40.9%
Avg. Op. Income Chg. - 3 Yr. 31.7%
Avg. EPS Growth - 3 Yr. 14.9%
Avg. EPS Growth - 1 Yr. 12.0%
Avg. Operating Margin 21.8%
Avg. LT Debt to Total Capital 33.3%
Avg. Return on Equity 19.9%
Dividend Yield 0%
Index Average Grade
Developed Markets (ex-Australia) Health Care Index 60.72
Country Breakdown
United States Of America 68.0%
Japan 12.0%
Denmark 8.0%
Korea, Republic Of 4.0%
Sweden 2.0%
Finland 2.0%
Ireland 2.0%
Switzerland 2.0%
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