MarketGrader Developed Markets (ex-Australia) Health Care Index


Five Largest Companies
Symbol Name Grade Market Cap Country
LLY Eli Lilly and Company 76.6 ¤1,146,052 US
JNJ Johnson & Johnson 51.2 ¤623,711 US
MRK Merck & Co., Inc. 54.0 ¤308,900 US
AZN.GB AstraZeneca PLC 60.0 ¤266,812 GB
NOVO.B.DK Novo Nordisk A/S Class B 75.0 ¤218,124 DK

Five Smallest Companies
Symbol Name Grade Market Cap Country
326030.KR SK Biopharmaceuticals Co., Ltd. 79.9 ¤4,305 KR
YPSN.CH Ypsomed Holding AG 69.3 ¤5,648 CH
ALK.B.DK ALK-abello A/S Class B 74.2 ¤8,208 DK
4151.JP Kyowa Kirin Co., Ltd. 66.8 ¤8,551 JP
HALO Halozyme Therapeutics, Inc. 72.9 ¤9,325 US

Companies with Most Selections Among Current Components
Symbol Name Grade Times* Country
NOVO.B.DK Novo Nordisk A/S Class B 75.0 38 DK
AMGN Amgen Inc. 61.8 31 US
ISRG Intuitive Surgical, Inc. 72.6 27 US
RMD ResMed Inc. 67.4 25 US
JNJ Johnson & Johnson 51.2 24 US
LLY Eli Lilly and Company 76.6 23 US
4507.JP Shionogi & Co., Ltd. 68.4 22 JP
BMY Bristol-Myers Squibb Company 61.9 22 US
4519.JP Chugai Pharmaceutical Co., Ltd. 66.0 21 JP
7741.JP HOYA CORPORATION 68.9 21 JP
*Number of times selected at Index semi-annual reconstitutions since inception date.
Index Bio
Average Market Cap ¤87,224
Median Market Cap ¤28,176
Avg. 3 Mo. Dollar Vol. ¤365,111,158
Avg. 3 Mo. Trading Vol. 2,757,302
Last Rebalance Date 03/23/2026
Companies Replaced 11
Biggest Industry Increase Medical Specialties
Biggest Industry Decrease Pharmaceuticals: Major

Fundamental Attributes
Trailing P/E Ratio (12 Mo.) 25.7
Forward P/E Ratio (12 Mo.) 18.7
Price/Book Ratio 6.4
Avg. Revenue Chg. - 3 Yr 40.9%
Avg. Op. Income Chg. - 3 Yr. 92.0%
Avg. EPS Growth - 3 Yr. 25.3%
Avg. EPS Growth - 1 Yr. 16.7%
Avg. Operating Margin 25.9%
Avg. LT Debt to Total Capital 25.9%
Avg. Return on Equity 23.0%
Dividend Yield 0.4%
Index Average Grade
Developed Markets (ex-Australia) Health Care Index 67.14
Country Breakdown
United States Of America 58.0%
Japan 14.0%
Korea, Republic Of 6.0%
Denmark 4.0%
United Kingdom 4.0%
Israel 2.0%
Finland 2.0%
France 2.0%
Belgium 2.0%
Switzerland 2.0%
Netherlands 2.0%
New Zealand 2.0%
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